| Time: | January 22, 2024, 2:00 p.m. (CET) |
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Prof. Dr. Stephan Nussberger
Abt. Biophysik, Institut für Biomaterialien und biomolekulare Systeme
Universität Stuttgart
The mitochondrial TOM complex (TOM) is the central gateway for newly synthesized proteins passing through the mitochondrial outer membrane. This talk will discuss our latest 3.3 Å cryo-EM structure of the complex and a 4 Å map detailing its interaction with a precursor protein at the late stage of translocation. By constraining the complex’s lateral mobility through physical interaction in the membrane, I will show that TOM responds to mechanical interactions, not just to biochemical signals. TOM may thus be the first indication of mechanosensitivity within the beta-barrel porin family, in addition to the already known mechanosensitivity of alpha-helical proteins.